别名
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洋茉莉腈; 3,4-亚甲二氧基苯甲腈; 3,4-亚甲二氧基苄腈; 3,4-(亚甲二氧基)苄腈; 1,3-苯并间二氧杂环戊烯-5-甲腈;
简介
本品可作香精香料。
CAS:444805-28-1
分子式:C27H52N3O7P
别名
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Brincidofovir
简介
Brincidofovir is an alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses. Upon oral administration, brincidofovir crosses the intestinal wall and penetrates target viral-infected cells before being cleaved to the free antiviral agent cidofovir. In turn, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Compared to cidofovir, which is given intravenously, hexadecyloxypropyl-cidofovir shows better oral bioavailability, less toxicity and enhanced cellular penetration.
别名
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二甲苯苯胺; 二甲苯磺酸; 二甲苯青
简介
可用作氧化还原指示剂(橙黄色-黄色)，生物染色剂，研究组织膜的渗透性测定以及金属镍中微量镁。
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