Brincidofovir is an alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses. Upon oral administration, brincidofovir crosses the intestinal wall and penetrates target viral-infected cells before being cleaved to the free antiviral agent cidofovir. In turn, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Compared to cidofovir, which is given intravenously, hexadecyloxypropyl-cidofovir shows better oral bioavailability, less toxicity and enhanced cellular penetration.

染料木素

MSDS

CAS:446-72-0

分子式:C15H10O5

别名

更多信息

金雀异黄酮; 4’,5,7-三羟基异黄酮; 5,7-二羟基-3-(4-羟苯基)-4H-1-苯并吡喃-4-酮; 染料木因; 金雀异黄素; 三羟基异黄酮; 染料木黄酮;

简介

一种来自豆制品的异黄酮。它抑制蛋白质酪氨酸激酶和拓扑异构酶-II（DNA 拓扑异构酶，II 型）活性，用作抗肿瘤剂和抗肿瘤剂。实验表明，它可以在人和鼠细胞系中诱导 G2 期停滞。此外，染料木素具有抗蠕虫活性。它已被确定为 Felmingia vesita 的活性成分，这是一种传统上用于对抗蠕虫的植物。它已被证明可有效治疗常见的肝吸虫、猪肉吸虫和家禽绦虫。此外，染料木黄酮是一种具有选择性雌激素受体调节剂特性的植物雌激素。它已在临床试验中作为经典激素疗法的替代品进行研究，以帮助预防绝经后妇女的心血管疾病。染料木素的天然来源包括豆腐、蚕豆、大豆、葛根和羽扇豆。

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